論文專著：
在J Biol Chem, Biochemistry, Protein Science等國內(nèi)外知名科技期刊上以第一作者（含共同第一作者）或通訊作者（含共同通訊作者）發(fā)表SCI論文70余篇。
發(fā)表英文論文：
1.Wang XB, Zhang CH, Zhang T, Li HZ, Liu YL, Xu ZG, Lei G, Cai CJ*, Guo ZY*. (2024) An efficient peptide ligase engineered from a bamboo asparaginyl endopeptidase. FEBS J. published online, doi: 10.1111/febs.17111.
2.Zheng YS, Liu YL, Xu ZG, He C*, Guo ZY*. (2024) Is myeloid-derived growth factor a ligand of the sphingosine-1-phosphate receptor 2? Biochem. Biophys. Res. Commun. 706: 149766.
3.Li HZ, Wang YF, Shao XX, Liu YL, Xu ZG, Wang SL, Guo ZY*. (2023) FAM237A, rather than peptide PEN and proCCK56-63, binds to and activates the orphan receptor GPR83. FEBS J. 290: 3461-3479.
4.Li HZ, Shao XX, Wang YF, Liu YL, Xu ZG, Guo ZY*. (2023) LEAP2 is a more conserved ligand than ghrelin for fish GHSRs. Biochimie 209: 10-19.
5.Li HZ, Wang YF, Zheng YS, Liu YL, Xu ZG, Guo ZY*. (2023) The ghrelin receptor GHSR has two efficient agonists in the lobe-finned fish Latimeria chalumnae. Biochem. Biophys. Res. Commun. 679: 110-115.
6.Li HZ, Wang YF, Hu WF, Liu YL, Xu ZG, Guo ZY*. (2023) Nanomolar range of FAM237B can activate receptor GPR83. Amino Acids 55: 1557-1562.
7.Zhang CH, Shao XX, Wang XB, Shou LL, Liu YL, Xu ZG, Guo ZY*. (2022) Development of a general bioluminescent activity assay for peptide ligases. FEBS Journal, 2022，289: 5241-5258.
8.Li HZ, Shao XX, Shou LL, Li N, Liu YL, Xu ZG, Guo ZY*. (2022) Development of Esterase-Resistant and Highly Active Ghrelin Analogs via Thiol-Ene Click Chemistry. ACS Med. Chem. Lett. 13: 1655-1662.
9.Li, Hao-Zheng; Shou, Li-Li; Shao, Xiao-Xia; Li, Ning; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*. (2021) LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish. Amino Acids, 2021, 53(6): 939-949.
10.Li, Hao-Zheng; Shao, Xiao-Xia; Shou, Li-Li; Li, Ning; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*. (2021) Unusual orthologs shed new light on the binding mechanism of ghrelin to its receptor GHSR1a. Archives of Biochemistry and Biophysics, 2021, 704: 108872.
11. Li, Hao-Zheng; Shou, Li-Li; Shao, Xiao-Xia; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun* .Identifying key residues and key interactions for the binding of LEAP2 to receptor GHSR1a. Biochemical Journal, 2020, 477(17): 3199-3217.
12. Li, Hao-Zheng; Li, Ning; Shao, Xiao-Xia; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*. Hydrophobic interactions of relaxin family peptide receptor 3 with ligands identified using a NanoBiT-based binding assay. Biochimie. 2020,177: 117-126.
13. Wang, Jia-Hui; Li, Hao-Zheng; Shao, Xiao-Xia; Nie, Wei-Han; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun* (2019) Identifying the binding mechanism of LEAP2 to receptor GHSR1a. FEBS Journal, 2019, 286(7): 1332-1345.
14. Wang, Jia-Hui; Nie, Wei-Han; Shao, Xiao-Xia; Li, Hao-Zheng; Hu, Meng -Jun; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun* .Exploring electrostatic interactions of relaxin family peptide receptor 3 and 4 with ligands using a NanoBiT-based binding assay. Biochimica et Biophysica Acta-Biomembranes, 2019, 1861(4): 776-786.
15. Wang, Jia-Hui; Shao, Xiao-Xia; Hu, Meng-Jun; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.Functionality of an absolutely conserved glycine residue in the chimeric relaxin family peptide R3/I5.Amino Acids, 2019, 51(4): 619-626.
16. Wang JH, Hu MJ, Zhang L, Shao XX, Lv CH, Liu YL, Xu ZG, Guo ZY* .Exploring receptor selectivity of the chimeric relaxin family peptide R3/I5 by incorporating unnatural amino acids. Biochimie. 2018,154: 77-85.
17. Hu MJ, Shao XX, Li HZ, Nie WH, Wang JH, Liu YL, Xu ZG, Guo ZY* .Development of a novel ligand binding assay for relaxin family peptide receptor 3 and 4 using NanoLuc complementation. Amino Acids 2018,50: 1111-1119.
18. Wang, Jia-Hui; Hu, Meng-Jun; Shao, Xiao-Xia; Wei, Dian; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.Cholesterol modulates the binding properties of human relaxin family peptide receptor 3 with its ligands.Archives of Biochemistry and Biophysics, 2018, 646: 24-30.
19. Hu, Meng-Jun; Wang, Jia-Hui; Shao, Xiao-Xia; Xu, Zeng-Guang; Guo, Zhan-Yun*.Overexpression of relaxin family peptide receptor 3 in Escherichia coli and characterization of its ligand binding properties.Process Biochemistry, 2018, 69: 131-135.
20.Wang Jia Hui; Shao Xiao Xia; Hu Meng Jun; Wei Dian; Nie Wei Han; Liu Ya Li; Xu Zeng Guang; Guo Zhan Yun*.Rapid preparation of bioluminescent tracers for relaxin family peptides using sortase-catalysed ligation.Amino Acids, 2017, 49(9): 1611-1617.
21.Wei Dian; Hu Meng Jun; Shao Xiao Xia; Wang Jia Hui; Nie Wei Han; Liu Ya Li; Xu Zeng Guang; Guo Zhan Yun*.Development of a selective agonist for relaxin family peptide receptor 3.Scientific Reports, 2017, 7(1): 3230.
22.Wang Jia Hui; Shao Xiao Xia; Hu Meng Jun; Wei Dian; Liu Ya Li; Xu Zeng Guang; Guo Zhan Yun*.A novel BRET-based binding assay for interaction studies of relaxin family peptide receptor 3 with its ligands.Amino Acids, 2017, 49(5): 895-903.
23.Hu Meng Jun; Wei Dian; Shao Xiao Xia; Wang Jia Hui; Liu Ya Li; Xu Zeng Guang; Guo Zhan Yun*.Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.Archives of Biochemistry and Biophysics, 2017, 619: 27-34.
24.Bruell, Shoni; Sethi, Ashish; Smith, Nicholas; Scott, Daniel J.; Hossain, Mohammed Akhter; Wu, Qing-Ping; Guo, Zhan-Yun; Petrie, Emma J.; Gooley, Paul R.*; Bathgate, Ross A. D.*.Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin.Scientific Reports, 2017, 7(1): 3294.
25.Hu Meng Jun; Shao Xiao Xia; Wang Jia Hui; Wei Dian; Liu Ya Li; Xu Zeng Guang; Guo Zhan Yun*.Identification of hydrophobic interactions between relaxin-3 and its receptor RXFP3: implication for a conformational change in the B-chain C-terminus during receptor binding.Amino Acids, 2016, 48(9): 2227-2236.
26.Liu Yu; Zhang Lei; Shao Xiao Xia; Hu Meng Jun; Liu Ya Li; Xu Zeng Guang; Guo Zhan Yun*.A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.Archives of Biochemistry and Biophysics, 2016, 604: 113-120.
27.Song Ge; Shao Xiao Xia; Wu Qing Ping; Xu Zeng Guang; Liu Ya Li; Guo Zhan Yun.Novel Bioluminescent Binding Assays for Ligand-Receptor Interaction Studies of the Fibroblast Growth Factor Family.PLos One, 2016, 11(7): e0159263.
28.Hu, Meng-Jun; Shao, Xiao-Xia; Wang, Jia-Hui; Wei, Dian; Guo, Yu-Qi; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.Scientific Reports, 2016, 6: 29648.
29.Chen Chen; Wang Jiahong; Cai Ruiping; Yuan Yanmeng; Guo Zhanyun; Grewer Christof; Zhang Zhou*.Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification.PLos One, 2016, 11(6): e0158319.
30.Liu, Ya-Li; Guo, Zhan-Yun*.Novel bioluminescent binding assays for interaction studies of protein/peptide hormones with their receptors.Amino Acids, 2016, 48(5): 1151-1160.
31.Wu, Qing-Ping; Zhang, Lei; Shao, Xiao-Xia; Wang, Jia-Hui; Gao, Yu; Xu, Zeng-Guang; Liu, Ya-Li*; Guo, Zhan-Yun*.Application of the novel bioluminescent ligand-receptor binding assay to relaxin-RXFP1 system for interaction studies.Amino Acids, 2016, 48(4): 1099-1107.
32.Song Ge; Wu Qing Ping; Xu Ting; Liu Ya Li; Xu Zeng Guang; Zhang Shi Fu; Guo Zhan Yun*.Quick preparation of nanoluciferase-based tracers for novel bioluminescent receptor-binding assays of protein hormones: Using erythropoietin as a model.Journal of Photochemistry and Photobiology B: Biology , 2015, 153: 311-316.
33.Wang Xiaomin; Guo Zhanyun*.Anti-gliomas Effect of Chlorotoxin-Conjugated Onconase at High Dose.Cell Biochemistry and Biophysics, 2015, 73(2): 389-392.
34.Liu Yu; Shao Xiao Xia; Zhang Lei; Song Ge; Liu Ya Li; Xu Zeng Guang; Guo Zhan Yun*.Novel bioluminescent receptor-binding assays for peptide hormones: using ghrelin as a model.Amino Acids, 2015, 47(10): 2237-2243.
35.Ji, Ben-Jun; Song, Ge; Zhang, Zhou; Guo, Zhan-Yun*.Efficient overexpression of human interleukin-6 in Escherichia coli using nanoluciferase as a fusion partner.Process Biochemistry, 2015, 50(10): 1618-1622.
36.Guo, Yu-Qi; Wu, Qing-Ping; Shao, Xiao-Xia; Shen, Ting; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.Secretory overexpression and isotopic labeling of the chimeric relaxin family peptide R3/I5 in Pichia pastoris.Amino Acids, 2015, 47(6): 1117-1125.
37.Liu Yu; Song Ge; Shao Xiao Xia; Liu Ya Li; Guo Zhan Yun*.Quantitative measurement of cell membrane receptor internalization by the nanoluciferase reporter: Using the G protein-coupled receptor RXFP3 as a model.Biochimica et Biophysica Acta-Biomembranes, 2015, 1848(2): 688-694.
38.He, Sheng-Xiang; Song, Ge; Shi, Jia-Ping; Guo, Yu-Qi; Guo, Zhan-Yun*.Nanoluciferase as a novel quantitative protein fusion tag: Application for overexpression and bioluminescent receptor-binding assays of human leukemia inhibitory factor.Biochimie, 2014, 106: 140-148.
39.Wang, Xin-Yi; Guo, Yu-Qi; Shao, Xiao-Xia; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions.Archives of Biochemistry and Biophysics, 2014, 558: 127-132.
40.Wang, Xin-Yi; Guo, Yu-Qi; Zhang, Wei-Jie; Shao, Xiao-Xia; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation.FEBS Journal, 2014, 281(13): 2927-2936.
41.Zhang, Wei-Jie; Wang, Xin-Yi; Guo, Yu-Qi; Luo, Xiao; Gao, Xue-Juan; Shao, Xiao-Xia; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.Amino Acids, 2014, 46(5): 1393-1402.
42.Zhang, Lei; Song, Ge; Xu, Ting; Wu, Qing-Ping; Shao, Xiao-Xia; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.A novel ultrasensitive bioluminescent receptor-binding assay of INSL3 through chemical conjugation with nanoluciferase.Biochimie, 2013, 95(12): 2454-2459.
43.Wang, Xiao-Min; Luo, Xiao; Guo, Zhan-Yun*.Recombinant expression and downstream processing of the disulfide-rich tumor-targeting peptide chlorotoxin.EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013, 6(4): 1049-1053.
44.Zhang, Wei-Jie; Jiang, Qian; Wang, Xin-Yi; Song, Ge; Shao, Xiao-Xia; Guo, Zhan-Yun*. A convenient method for europium-labeling of a recombinant chimeric relaxin family peptide R3/I5 for receptor-binding assays.Journal of Peptide Science, 2013, 19(6): 350-354.
45.Song, Ge; Jiang, Qian; Xu, Ting; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.A convenient luminescence assay of ferroportin internalization to study its interaction with hepcidin.FEBS Journal, 2013, 280(8): 1773-1781.
46.Zhang, Wei-Jie; Gao, Xue-Juan; Liu, Ya-Li; Shao, Xiao-Xia; Guo, Zhan-Yun*.Design, recombinant preparation and europium-labeling of a fully active easily-labeled INSL3 analog for receptor-binding assays.Process Biochemistry, 2012, 47(12): 1856-1860.
47.Luo, Xiao; Jiang, Qian; Song, Ge; Liu, Ya-Li; Xu, Zeng-Guang; Guo, Zhan-Yun*.Efficient oxidative folding and site-specific labeling of human hepcidin to study its interaction with receptor ferroportin.FEBS Journal, 2012, 279(17): 3166-3175.
48.Zhang, Wei-Jie; Luo, Xiao; Liu, Ya-Li; Shao, Xiao-Xia; Wade, John D.; Bathgate, Ross A. D.; Guo, Zhan-Yun*.Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies.Amino Acids, 2012, 43(2): 983-992.
49.Zhang, Wei-Jie; Luo, Xiao; Song, Ge; Wang, Xin-Yi; Shao, Xiao-Xia; Guo, Zhan-Yun*.Design, recombinant expression and convenient A-chain N-terminal europium-labelling of a fully active human relaxin-3 analogue.FEBS Journal, 2012, 279(8): 1505-1512.
50.Chen, Guo-Wu; Luo, Xiao; Liu, Ya-Li; Jiang, Qian; Qian, Xian-Ming; Guo, Zhan-Yun*.R171H missense mutation of INSL6 in a patient with spermatogenic failure.European Journal of Medical Genetics, 2011, 54(4): e455-e457.
51.Luo, Xiao; Huang, Chun-Hua; Shao, Xiao-Xia; Guo, Zhan-Yun*.Design, recombinant expression and in vitro maturation of human insulin-like peptide 6 and a biotin-labeled analogue.Process Biochemistry, 2011, 46(6): 1243-1247.
52.Luo, Xiao; Liu, Ya-Li; Layfield, Sharon; Shao, Xiao-Xia; Bathgate, Ross A. D.*; Wade, John D.; Guo, Zhan-Yun.A simple approach for the preparation of mature human relaxin-3.Peptides, 2010, 31(11): 2083-2088.
53.Wu, Xuechen; Shao, Xiaoxia; Guo, Zhan-Yun; Chi, Cheng-Wu.Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus. Acta Biochimica et Biophysica Sinica, 2010, 42(7): 502-505.
54. Luo X, Bathgate RA, Zhang WJ, Liu YL, Shao XX, Wade JD*, Guo ZY*. (2010) Design and recombinant expression of insulin-like peptide 5 (INSL5) precursors and the preparation of mature human INSL5. Amino Acids, 2010, 39(5): 1343-1352. (* corresponding authors)
55. Wu XC, Zhou M, Peng C, Shao XX, Guo ZY*, Chi CW* (2010) Novel conopeptides in a form of disulfide-crosslinked dimer. Peptides, 2010, 31(6): 1001-1006. (* corresponding authors)
56. Wang ZQ, Zhou ZM, Guo ZY*, Chi CW* (2010) Snapshot of the interaction between HIV envelope glycoprotein 120 and protein disulfide isomerase. Acta Biochimica et Biophysica Sinica, 2010, 42(5): 358-362. (* corresponding authors)
57. Zhang WJ, Luo X, Guo ZY* (2010) In Vitro Degradation of Insulin-like Peptide 3 by Insulin-Degrading Enzyme. Protein Journal, 2010, 29(2): 93-98. (* corresponding author)
58. Luo X, Bathgate RA, Liu YL, Shao XX, Wade JD*, Guo ZY*. (2009) Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3. FEBS Journal, 2009, 276(18): 5203-5211. (*corresponding authors)
59. Yuan, Duo-Duo; Liu, Li; Shao, Xiao-Xia; Peng, Can; Chi, Cheng-Wu; Guo, Zhan-Yun* (2009) New conotoxins define the novel I3-superfamily. PEPTIDES, 2009, 30(5): 861-865. (*corresponding authors)
60. Liu, Ya-Li; Jiang, Shu; Ke, Zu-Min; Wu, Hai-Shui; Chi, Cheng-Wu; Guo, Zhan-Yun* (2009) Recombinant expression of a chitosanase and its application in chitosan oligosaccharide production. CARBOHYDRATE RESEARCH, 2009, 344(6): 815-819. (*corresponding author)
61.Zhao Jie; Huang Qi Long; Tang Yue Hua; Guo Zhan Yun; Qiao Zhi Song; Xu Gen Jun; Feng You Min*.Equilibrium folding of porcine insulin precursor in the presence of redox buffer: Implications for the common intermediates shared by its unfolding/refolding processes.Protein and Peptide Letters, 2008, 15(9): 972-979.
62. Yuan DD, Liu L, Shao XX, Peng C, Chi CW*, Guo ZY* (2008) Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus. Peptides, 2008, 29(9): 1521-1525. (*corresponding authors)
63. Qian J, Guo ZY*, Chi CW*. (2008) Cloning and isolation of a conus cysteine-rich protein homologous to Tex31 but without proteolytic activity. Acta Biochimica et Biophysica Sinica, 2008, 40(2): 174-181. (*corresponding authors)
64. Zhang ZJ, Wu L, Qiao ZS, Qiao MQ, Feng YM*, Guo ZY* (2008) Contribution of the conserved A16Leu to insulin foldability. Protein Journal, 2008, 27(3): 192-196. (*corresponding authors)
65. Guo ZY*, Qiao ZS*, Feng YM (2008) The in vitro oxidative folding of the insulin superfamily. Antioxidants and Redox Signaling, 2008, 10(1): 127-139. (*co-first authors)
66. Guo ZY, Chang CCY, Chang TY (2007) Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1. Biochemistry,46: 10063-10071.
67. Wang, Zhi-Qiang; Han, Yu-Hong; Shao, Xiao-Xia; Chi, Cheng-Wu; Guo, Zhan-Yun* (2007) Molecular cloning, expression, and characterization of protein disulfide isomerase from Conus marmoreus. FEBS JOURNAL, 2007, 274(18): 4778-4787..(*corresponding authors)
68. Guo ZY, Lin S, Henien JA, Chang CY, Chang TY (2005) The active site His-460 of human acyl-coenzyme A: cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain. J Biol Chem, 280: 37814-37826.
69. Guo ZY, Chang CY, Lu X, Chen J, Li BL, Chang TY (2005) The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide. Biochemistry, 44: 6537-6546.
70. Guo ZY, Zhang Z, Jia XY, Tang YH, Feng YM (2005) Mutational analysis of the absolutely conserved B8Gly: consequence on foldability and activity of insulin. Acta Biochim Biophys Sin,37: 673-679.
71. Guo ZY, Jia XY, Feng YM (2004) Replacement of the interchain disulfide-forming amino acids A7 and B7 by glutamate impairs the structure and activity of insulin. Biol Chem, 385:1171-1175.
72. Guo ZY, Wang S, Tang YH, Feng YM (2004) Mutagenesis of the three conserved valine residues: consequence on the foldability of insulin. Biochim Biophys Acta, 1699: 103-109.
73. Jia XY*, Guo ZY*, Wang Y, Xu Y, Duan SS, Feng YM (2003) Peptide models of four possible insulin folding intermediates with two disulfides. Protein Sci, 12: 2412-2419. (*co- first authors)
74. Wang S*, Guo ZY*, Shen L, Feng YM (2003) Refolding of the amphioxus insulin-like peptide: implications of a bifurcating evolution of the different folding behaviors of insulin and insulin-like growth factor 1. Biochemistry, 42: 9687-9693. (*co-first authors)
75. Guo ZY, Tang YH, Wang S, Feng YM (2003) Contribution of the absolutely conserved B8Gly to the foldability of insulin. Biol Chem, 384: 805-809.
76. Yan H*, Guo ZY*, Gong YW, Xi D, Feng YM (2003) A peptide model of insulin folding intermediate with one disulfide. Protein Sci, 12: 768-775. (*co-first authors)
77. Guo ZY, Shen L, Gu W, Wu AZ, Ma JG., Feng YM (2002) In vitro evolution of amphioxus insulin-like peptide to mammalian insulin. Biochemistry, 41: 10603-10607.
78. Guo ZY, Shen L, Feng YM (2002) The different energetic state of the intra A-chain/ domain disulfide of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain. Biochemistry, 41: 10585-10592.
79. Guo ZY, Shen L, Feng YM (2002) The different folding behavior of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain. Biochemistry, 41: 1556-1567.
80. Guo ZY, Feng YM (2002) The thermodynamic stability of insulin disulfides is not affected by the C-domain of insulin-like growth factor 1. Sci China (Series C), 45: 245-250.
81. Guo ZY, Feng YM (2001) Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin. Biol Chem, 382: 443-448
82. Guo ZY, Tang YH, Zhang Z, Feng YM (2001) Mutational analysis of the three conserved valine residues of insulin and a proposal of “isosteric residue”. IUBMB Life, 52: 309-314.
83. Guo ZY, Qiao ZS, Feng YM (2001) Unfolding of recombinant single-chain insulin in denaturants containing thiol reagents. Acta Biochim Biophys Sin, 33: 65-70.
84. Shen L*, Guo ZY*, Chen Y, Liu LY, Feng YM (2001) Expression, purification, characterization of ampioxus insulin-like peptide and preparation of polyclonal antibody to it.Acta Biochim Biophys Sin, 33: 629-633. (*co-first authors)
發(fā)表中文期刊論文：
[1]黃碧君,黃艷,胡紅琴,郭占云.毛細(xì)管電泳法測定重組人源化IgG2抗體的純度[J].中國生物制品學(xué)雜志,2018,31(03):287-293+298.
[2]劉亞麗,郭占云.蛋白質(zhì)多肽激素生物發(fā)光配基-受體結(jié)合測定新方法[J].生命的化學(xué),2015,35(06):817-822.
[3]邵曉霞,汪世龍,郭占云.蛋白質(zhì)化學(xué)實(shí)驗(yàn)課教學(xué)探索[J].課程教育研究,2015(13):147.
[4]周宛虹,邵曉霞,郭占云.吸煙者血清中尼古丁及其多種代謝物的測定與代謝分析[J].現(xiàn)代科學(xué)儀器,2013(01):122-125.
[5]田昀,張柿平,郭占云.酶解法制備殼寡糖的初步研究[J].安徽農(nóng)業(yè)科學(xué),2010,38(04):1684-1686.
[6]王志強(qiáng),周智敏,郭占云.蛋白質(zhì)二硫鍵異構(gòu)酶家族的結(jié)構(gòu)與功能[J].生命科學(xué)研究,2009,13(06):548-553.
[7]徐瑞,郭占云,戚正武.殼聚糖酶的純化、基因克隆、及其酶學(xué)特性的鑒定[J].藥物生物技術(shù),2008(02):94-99.
[8]何勝祥,陳平,郭占云,邵曉霞.蛋白質(zhì)組學(xué)在神經(jīng)退行性疾病中的研究進(jìn)展[J].細(xì)胞生物學(xué)雜志,2007(02):173-178.
[9]閆菡 ,郭占云 ,馮佑民.大分子擁擠及其對蛋白質(zhì)折疊的影響[J].陜西醫(yī)學(xué)雜志,2003(03):246-247.
[10]郭占云,馮佑民.類胰島素生長因子-1的C結(jié)構(gòu)域不影響胰島素二硫鍵的熱力學(xué)穩(wěn)定性[J].中國科學(xué)(C輯:生命科學(xué)),2002(01):84-88.
[11]沈璐,郭占云,陳衍,劉蘭英,馮佑民.文昌魚胰島素樣肽的表達(dá)、純化、鑒定及其多克隆抗體制備[J].生物化學(xué)與生物物理學(xué)報(bào),2001(06):629-633.
[12]郭占云,喬志松,馮佑民.重組單鏈胰島素在含有巰基試劑的變性劑中的解折疊[J].生物化學(xué)與生物物理學(xué)報(bào),2001(04):431-436.
發(fā)表中文會議論文：
[1]彭燦;陳偉華;Tanya Sanders;Geoffrey Chew;Edward Hawrot;戚正武;郭占云. Characterization of two α4/7-conotoxins,Mrl.1 and Lpl.4,as novel antagonists of nicotinic acetylcholine receptors[C]. 第九屆中國生物毒素學(xué)術(shù)研討會論文摘要. 2009:61.
[2]吳雪塵; 周宓; 郭占云; 戚正武. Novel disulfide-crosslinked dimeric conopeptides cloned based on M-superfamily signal peptide[C]. 第九屆中國生物毒素學(xué)術(shù)研討會論文摘要. 2009:63.
[3]袁多多;劉麗;郭占云;戚正武. 新型I3-超家族芋螺毒素的分離純化及基因克隆[C]. 第八屆中國生物毒素學(xué)術(shù)研討會論文摘要集. 2007:102.
[4]袁多多;劉麗;郭占云;戚正武. 從唐草芋螺中分離及克隆含有新型半胱氨酸骨架的芋螺毒素[C]. 第八屆中國生物毒素學(xué)術(shù)研討會論文摘要集. 2007:105.
[5]袁多多;劉麗;郭占云;戚正武. 唐草芋螺中α-芋螺毒素的分離純化及基因克隆[C]. 第八屆中國生物毒素學(xué)術(shù)研討會論文摘要集. 2007:106.
[6]袁多多; 劉麗; 郭占云; 戚正武. 新型I3-超家族芋螺毒素的分離純化及基因克隆[C]. 第八屆中國生物毒素學(xué)術(shù)研討會論文摘要. 2007:102.
[7]袁多多; 劉麗; 郭占云; 戚正武. 從唐草芋螺中分離及克隆含有新型半胱氨酸骨架的芋螺毒素[C]. 第八屆中國生物毒素學(xué)術(shù)研討會論文摘要. 2007:105.
[8]袁多多; 劉麗; 郭占云; 戚正武. 唐草芋螺中α-芋螺毒素的分離純化及基因克隆[C 第八屆中國生物毒素學(xué)術(shù)研討會論文摘要. 2007:106.
郭占云 ，男，博士，研究員，博士生導(dǎo)師。1972年生，河北灤南人。1996年畢業(yè)于吉林大學(xué)分子生物學(xué)系，獲學(xué)士學(xué)位。同年免試進(jìn)入中國科學(xué)院上海生物化學(xué)研究所攻讀博士學(xué)位，在馮佑民研究員實(shí)驗(yàn)室從事胰島素超家族多肽研究，2001年8月獲生物化學(xué)與分子生物學(xué)博士學(xué)位。2001-2003年在中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所工作，歷任助理研究員和副研究員。2003年9月到美國Dartmouth College醫(yī)學(xué)院從事博士后研究，主要研究膽固醇酯合酶1（ACAT1）的結(jié)構(gòu)與功能。2006年底回國到同濟(jì)大學(xué)生命科學(xué)與技術(shù)學(xué)院蛋白質(zhì)研究所工作，主要從事蛋白質(zhì)多肽激素與G蛋白偶聯(lián)受體（GPCR）相互作用研究。以通訊作者或第一作者發(fā)表SCI論文70余篇，累計(jì)影響因子超過200，被引用1400余次。已主持國家自然科學(xué)基金面上項(xiàng)目6項(xiàng)，國家“重大新藥創(chuàng)制”科技重大專項(xiàng)1項(xiàng)，國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃課題1項(xiàng)。曾任中國生物化學(xué)與分子生物學(xué)會理事、上海市生物化學(xué)與分子生物學(xué)學(xué)會理事，現(xiàn)任現(xiàn)任同濟(jì)大學(xué)生命科學(xué)與技術(shù)學(xué)院蛋白質(zhì)研究所研究員，博士生導(dǎo)師。
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