先后獲得國內(nèi)外獎(jiǎng)項(xiàng)有：美國Amherst, MA.和Pacific Grove, CA.乙肝分子生物學(xué)特別獎(jiǎng)（2001年和2002年）﹑德國細(xì)胞生物學(xué)創(chuàng)新獎(jiǎng)（2007年）、美國圣地亞哥3DBiotek“The Industrial Recognized 3-Dimensional Cell Culture International Expert”(工業(yè)界認(rèn)可的三維細(xì)胞培養(yǎng)領(lǐng)域國際知名專家)稱號（2010年）、“華創(chuàng)杯”優(yōu)秀項(xiàng)目獎(jiǎng)（2010年）、武漢市東湖開發(fā)區(qū)“3551”光谷創(chuàng)業(yè)人才計(jì)劃（2010年），湖北省“百人計(jì)劃”特聘專家（2012年），并擔(dān)任德國Friedrich-Ebert-基金會生命科學(xué)導(dǎo)師﹑Virology & Retro Virology 、《中國組織工程與臨床康復(fù)》、《世界華人消化雜志》、《病毒學(xué)報(bào)》等多家學(xué)術(shù)期刊編委，是國家科學(xué)技術(shù)獎(jiǎng)勵(lì)評審專家、科技部國際重大合作項(xiàng)目終審專家及教育部長江學(xué)者評審專家。
教育經(jīng)歷：
1995年至1999年：Dr. rer. nat (magna cum laude) 德國杜賽爾多夫(Duesseldorf)大學(xué)物理生物研究所分子病毒學(xué)專業(yè)自然科學(xué)博士（最優(yōu)等）導(dǎo)師：Prof. Dr. D. Riesner (馬普獎(jiǎng)獲得者，世界多家大型生物集團(tuán)公司董事會主席) 。
1、Selection of chemical drugs as inhibitor of citrus exocortis viroid (M. Sci., 1985-1988)
2、Cloning and expression of human growth hormone releasing factor gene (supported by the key project Chinese Academy of Sciences, 1988-1990) with Prof. Dr. Daming Ding
3、Biochemical analysis of citrus exocortis viroid (supported by the Chinese National Eighth 5-year Plan, key project, 1990-1994) with Prof. Dr. Daming Ding
4、RNA transcription aspect of viroid replication (Ph. D and Postdoc fellow, Funds of Chemistry Industry, Düsseldorf, 1996-2000) with Prof. Dr. Detlev Riesner
5、In vitro selection of duck Hepatitis B virus epsilon variants with higher affinity for P protein (Postdoc work, German Research Foundation, Freiburg, 2000-2003) with Prof. Dr. Michael Nassal
6、Mechanism of liver fibrosis (Senior Scientist, German Research Foundation and EU project, Regensburg, 2003-2005) with Prof. Dr. Jürgen Schoemerich and Dr. Bernd Schnabl
7、Developmental biology of kidneys (C1 Professor, German Research Foundation, Regensburg, 2006-2008) with Prof. Dr. Will Minuth
8、Study of the replication of hepatitis B virus (Research Professor, Chinese Academy of Sciences, key project, 2008-2011)
9、In vitro screening of anti HBV decoys using selex approach (Research Professor, National Natural Science Foundation of China, General Project 2009-2011)
10、Establishment of in vitro cellular model susceptible to HBV infection (Research Professor, National 11th five-year Plan Major Science and Technology Special Project in the Field of Infectious Diseases, 2009-2011)
11、Optimization and application of in vitro cellular model susceptible to HBV infection (Research Professor, National 12th five-year Plan Major Science and Technology Special Project in the Field of Infectious Diseases, 2011-2015)
12、Screening of anti-HBV drugs and application of 3DCC in the field of regenerative medicine (Professor and Director, Initial Project of Hubei University of Technology, 2014-2015)
13、Hu3D® 3DCC equipment: R&D and industrialization (Professor and Director, Major Project of University-Enterprise Cooperation, 2014-2023)
14、In vivo study on the anti HBV efficacy of RNA decoys (Key Project of Hubei Provincial Natural Science Foundation, 2015-2017)
15、Directional differentiation technology system for pancreatic islets derived from pluripotent stem cells (Hubei Province Key R&D Plan (Social Development Field,2022-2024)
主持的科研項(xiàng)目：
1、Underlying mechanism of liver fibrosis (Senior Scientist, German Research Foundation and EU project, Regensburg, 歐盟聯(lián)合課題，2003-2005) 。
2、Tissue engineering and regeneration medicine of kidney(C1 Professor, German Research Foundation, Regensburg, 德國自然科學(xué)基金, 歐盟聯(lián)合課題，2006-2008)。
3、Application of perfusion 3D cell culture technique in virology (PI, EU Project III. UNOCFG3，2008.03-2012.06) 。
3、胡康洪合著《中國學(xué)科發(fā)展戰(zhàn)略再生醫(yī)學(xué)》2017 ISBN 978-7-03-043400-5，科學(xué)出版社
4、Minuth WW, Strehl R & Hu KH《3D Kulturen-Zellen, Kultursysteme und Environment》2006 ISBN 978-3-89967-316-2 Pabst Science Publishers
發(fā)表期刊論文： (* 通訊作者)
2024年：
[112] WEITAO ZHENG; DONG JIANG; SONGEN CHEN; MEILING WU; BAOQI YAN; JIAHUI ZHAI; YUNQIANG SHI; BIN XIE;XINGWANG XIE; KANGHONG HU*; WENXUE MA*.Exploring the therapeutic potential of precision T-Cell Receptors (TCRs) in targeting KRAS G12D cancer through in vitro development.Oncology Research .2024,32(12):1837-1850. PDF
[105]Yanhong Wei, Huihui Liu, Da Hu, Qun He, Chenguang Yao, Hanluo Li, Kanghong Hu,*,Jun Wang,*.Recent Advances in Enterovirus A71 Infection and Antiviral Agents.Lab Invest 104 (2024) 100298. https://doi.org/10.1016/j.labinv.2023.100298.PDF
2023年：
[104]Qian Peng , Jialu Qiao , Weiling Li , Qiang You , Song Hu , Yuchen Liu , Wei Liu , Kanghong Hu* , Binlian Sun .Global m6A methylation and gene expression patterns in human microglial HMC3 cells infected with HIV-1.Heliyon . 2023 Oct 26;9(11):e21307. https://doi: 10.1016/j.heliyon.2023.e21307. eCollection 2023 Nov.PDF
[103]Kanghong Hu et al. 2023 “EV-A71 mechanism of entry: receptors/co-receptors, related pathways and inhibitors “ Viruses 15,785. https://doi.org/10.3390/v15030785.PDF
[102]Kanghong Hu et al. 2023 “Legume-derived bioactive peptides in type 2 diabetes: opportunities and challenges“ Nutrients 15,1096. doi.org/10.3390/nu15051096.PDF
[101]Rominah Onintsoa Diarimalala, Yanhong Wei, Da Hu and Kanghong Hu* 2023 “Inflammasomes during SARS-CoV-2 infection and development of their corresponding inhibitors” Front. Cell. Infect. Microbiol. 13:1218039. https://doi.org/10.3389/fcimb.2023.1218039.PDF
[100]Jingsong Cui , Haiping Wang, Fang Yang, Qian Peng, Weiling Li, Kanghong Hu*, Binlian Sun* 2023 “PCN224 mediated sono-photodynamic therapy triggers apoptosis through multisite damage in hepa1-6 Cells” J. Biol. Regul. Homeost. Agents. 37(4): 1819-1828 https://doi.org/10.23812/j.biol.regul.homeost.agents.20233704.181.PDF
[99]Yanhong Wei, Da Hu, Dong Li, Kanghong Hu et al. 2023 “ Antiviral effects and mechanisms against EV71 of the novel 2-benzoxyl-phenylpyridine derivatives“ Eur J Pharm Sci 186:106445. doi:10.1016/j.ejps.2023.106445.PDF
[90]Chen Z, Wang Y, Wang X, Xiao Z, Wu P*,Hu K* 2022 “Rational design and synthesis of organic-inorganic hexavanadate hybrids with p-halogenated benzoyl ligands” Journal of Molecular Structure 131451.PDF
[89]Wang LS*, Guo C, Hu D, Zhao YX, Liu HH, Dong YJ, Sun SB, Liu X, Hu KH & Wei YH* 2022“Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates” Frontiers in Chemistrydoi:10.3389/fchem.2022.841151.PDF
[88]Qinglin Ding, Hanluo Li, Zhigao Xu, Kanghong Hu* and Qifa Ye* 2022 “Identification of CFHR4 associated with poor prognosis of hepatocellular carcinoma” Front. Oncol. 12:812663 doi: 10.3389/fonc.2022.812663.PDF
[86]Zhen WT, Li HL, Hu KH et al. 2021 “Chondromalacia patellae:current option and emerging cell therapies” Stem Cell Research & Therapy 12:412 doi.org/10.1186/s13287-021-02478-4.PDF
[85]Zhang RJ, Bao J, Qiao JL, Li WS, Feng Q, Hu KH * and Sun BL* 2021 “Long-term efavirenz exposure induced neuroinflammation and cognitive deficits in C57BL/6 mice” Biochemical and Biophysical Research Communication584:46-52.PDF
[82]Wei Yanhong, Wang Haijie, Xi Caili, Li Ni, Li Dong, Yao Chengguang, Sun Ge, Ge Hongmei, Hu Kanghong* and Zhang Qian* 2020 “Antiviral effects of novel 2-benzoxyl-phenylpyridine derivatives”. Molecules, 2020, 25(6): 1409.;doi:10.3390/molecules25061409.PDF
[81]Rominah OD, Hu M, Wei Y, Hu KH* 2020 “Recent advances of enterovirus 71 3Cpro targeting inhibitors” Virology Journal 17:173 doi.org/10.1186/s12985-020-01430-x.PDF
[80]Huang, Bo; Ke, Degang; Xiong, Zhelun; Wang, Yu; Hu, Kanghong; Jiang, Peng; Liang, Minghui; Xiao, Zicheng; Wu, Pingfan.Covalent hybrid materials between polyoxometalates and organic molecules for enhanced electrochemical properties.Journal of Materials Science, 2020, 55(13): 5554-5570. doi.org/10.1007/s10853-020-04404-0.PDF
[74]Yao, Chenguang; Hu, Kanghong; Xi, Caili; Li, Ni; Wei, Yanhong* 2019 "Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene". Genes & Genomics, 2019, 41(3): 343-357. doi: 10.1007/s13258-018-0760-7.PDF
[73]Xiaokang Hu, Huan Wang, Bo Huang, Ni Li, Kanghong Hu*; Baolin Wu; Zicheng Xiao; Yanhong Wei; Pingfan Wu. 2019 "A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities" Journal of Inorganic Biochemistry193:130-132.PDF
[69]Yao Chenguang; Xi Caili; Hu Kanghong; Gao Wa; Cai Xiaofeng; Qin Jinlan; Lv Shiyun; Du Canghao; Wei Yanhong*. 2018 "Inhibition of enterovirus 71 replication and viral 3C protease by quercetin". Virology Journal 2018,15(1):116. doi: 10.1186/s12985-018-1023-6.PDF
[68]Min Cheng; Ni Li; Nan Wang; Kanghong Hu; Zicheng Xiao; Pingfan Wu; Yanhong Wei. 2018 "Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network"Polyhedron 2018,155:313-319.PDF
2017年
[67]HU Kanghong et al. 2017 “KNK437 Inhibits Replication and Transcription of the Hepatitis B Virus”Chinese Journal of Virology (English Version) 01:24-35.PDF
[66]Mengying Ji and Kanghong Hu*. 2017 "Recent advances in the study of hepatitis B virus covalently closed circular DNA"Virologica Sinica,2017,32(6):454-464.PDF
[65]Guoguo Ye, Ge Sun, Zhikui Cheng, Lei Zhang, Kanghong Hu et al. 2017 “p55PIK regulates alpha-fetoprotein expression through the NF-κB signaling pathway“ Life Sci. 191,104-110.PDF
[64]朱祥,堯晨光,胡康洪. 腸道病毒71型感染相關(guān)調(diào)控樞紐基因篩選[J]. 生物信息學(xué),2017,15(04):242-248. PDF
[60]Cheng Z, Zhi X, Sun G, Guo W, Huang Y, Sun W, Tian X, Zhao F, Hu K*. 2016 “Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines” Journal of Medical Virology 88(4):653-663.PDF
[59]Ke Peng; Sun Honghao; Liu Mingxing; Su Zhengding; Hu Kanghong; Zhua Hongda; Guo Huilin; Sun Hongmei; Andresen Thomas Lars; Olsen Lars Folke. “Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide”IET Nanobiotechnol.2016, 10(1): 8-12.PDF
[58]Xiaoli Ye, Ming Zhou, Yonggang He, Yanmin Wan, Weiya Bai, Shuai Tao, Yanqin Ren, Xinxin Zhang, Jianqing Xu, Jing Liu, Junqi Zhang, Kanghong Hu* et al. 2016 “Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide”Scientific Reports 6:29391DOI: 10.1038/srep29391.PDF
[53]Danzhen Pan , Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang, Chunchen Wu, Xinwen Chen, Kanghong Hu et al. 2015“Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model” PlosOne 10(5):e0125658.PDF
[52]Zhikui Cheng; Ge Sun; Wei Guo; Yayun Huang; Weihua Sun; Fei Zhao; Kanghong Hu* .2015 “Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines”.Virol Sinica .2015,30(4):261-268.PDF
[48]Zhou M, Zhao F, Li J, Cheng Z, Tian X, Zhi X, Huang Y, Hu K* .2014“Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells”J Virol Methods 195:185-193.PDF
[47]Tian Xiaohui, Zhao Fei, Sun Weihua, Zhi Xiaoguang, Hu Kanghong * .2014 CRTC2 enhances HBV transcription and replication by inducing PGC1alpha expression.Virology Journal 11:30, doi: 10.1186/1743-422X-11-30.PDF
[46]Ming Zhou, Yayun Huang, Zhikui Cheng, Fei Zhao, Jiafu Li, Xiaoguang Zhi,Xiaohui Tian, Weihua Sun, Kanghong Hu∗ .2014 “Revival, characterization, and hepatitis B virus infection ofcryopreserved human fetal hepatocytes”. Journal of Virological Methods, 2014, 207: 29-37. PDF
[44]黃亞運(yùn); 胡康洪* . 抗乙肝病毒治療新策略:阻斷P-ε相互作用[J]. 病毒學(xué)報(bào),2014,30(06):713-720. PDF
2013年
[43]Wang W, Peng H, Li J, Zhao X, Zhao F, Hu K*. 2013“Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector.”Virus Genes 46(3):393-403.PDF
[42] Feng H, Chen P, Zhao F, Nassal M, Hu K* .2013“Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription” PlosOne 8(8):e72798.PDF
[41] Chen P, Yun G, Li J, Zhao F, Rayner S*, Hu K*. 2013“Computational Evolutionary Analysis of the Overlapped Surface (S) and Polymerase (P) Region in Hepatitis B Virus Indicates the Spacer Domain in P Is Crucial for Survival”PlosOne 8(4):e60098.PDF
[40]Pan X, Li XJ, Liu XJ, Tian XH, Hu K et al. 2013 “Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection” J Virol. 87(20):10968-10979.PDF
[38]Zhao Z, Hong W, Zeng Z, Wu Y, Hu K et al.2012 “Mucroporin-M1 Inhibits Hepatitis B Virus Replication by Activating the Mitogen-activated Protein Kinase (MAPK) Pathway and Down-regulating HNF4 in Vitro and in Vivo.” J Biol Chem. 287(36):30181-90.PDF
[36]Feng H , Beck J, Nassal M and Hu K*. 2011“A SELEX-Screened Aptamer of Human Hepatitis B Virus RNA Encapsidation Signal Suppresses Viral Replication”PlosOne 6(11):e27862.PDF
[35]Chen P, Rayner S, Hu K*. 2011 “Advances of Bioinformatics Tools Applied in Virus Epitopes Prediction”Virol Sinica. 26(1):1-7.PDF
[26]Feng H and Hu K* .2009 “Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase”. Virologica Sinica.24(6)：509-517.PDF
[17]Hu K et al. 2007“Chemically defined medium environment for the development of renal stem cells into tubules”. Biotech J 2(8):992-995.PDF
[16]Heber S, Denk L, Hu K* et al 2007 “Modulating the Development of Renal Tubules Growing in Serum-Free Culture Medium at an Artificial Interstitium” Tiss Engi,13(2), 281-292.PDF
[15]Will W Minuth; Lucia Denk; Kanghong Hu*. “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium” Biomaterials. 2007, (30): 4418-4428.PDF
[14]Minuth WW, Denk L, Hu K et al. 2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor”. Central Europ J Biol,2(3), 307-325.PDF
[13]Minuth WW,Hu K*, Denk L. 2007“Kontrolliertes Environment für Stammzellen – Generierung renaler Tubuli in chemisch definiertem Kulturmedium“Bioforum 4:28-29.PDF
[12]Minuth WW, Denk L and Hu K*. 2007“Kontrolliertes Environment für die Entwicklung von Stammzellen zu renalen Tubuli” Regener Medizin 2(1):22-27.PDF
[11]Ke B. and Hu K *. 2007 "Environmental pollution and skin diseases" Medical Recapitulate 13(18), 1377-1379.PDF
2006年
[10]Nadine K., Oliver B., Ashermann K.,Hu K. et al. 2006 “Transcription of potato spindle tuber viroid by RNA polymerase II starts in the left terminal loop” Virology. 347(2), 392-404.PDF
2005年
[9]Schnabl B, Hu K. et al.2005 “Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10” Biochemi Biophys Res Communi 335, 87-96.PDF
[8]Hu K et al.2005“Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y” Biochimica et Biophysica Acta 1729:14-23.PDF
2004年
[7]Hu K. et al 2004 “SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription” Nucleic Acids Research 32(14):4377-4389.PDF
2001年
[6]Fels A,Hu K et al.2001 “Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites”Nucleic Acids Research 29(22), 4589-4597.PDF
2001年以前的
[5]Hu K. 2000 “Wechselwirkung beider Startstellen der Transkription von mutierten zirkulären Viroidmolekülen” Dissertation, Heinrich-Heine-Universität Düsseldorf, Germany 1-120 (in German). PDF
[4]Xiong K., Jin R., Hu K. and Ding D. 1990 "Chemically Synthesis and Cloning of the Human Growth Hormone Releasing Factor Gene"Chinese Journal of Biotechnology (English Version) 6, 243-250.PDF
3. Xiaokang Hu, Huan Wang, Bo Huang, Ni Li, Kanghong Hu* et al. 2019 “A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities” Journal of Inorganic Biochemistry 193:130-132 doi: 10.1016/J.JINORGBIO.2019.01.013
4. Yao Chengguang#, Hu Kanghong# et al. 2019 “Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene” Genes & Genomics 41(3):343-357. doi: 10.1007/s13258-018-0760-7
5. Yao Chengguang, Xi Caili, Hu Kanghong, Gao Wa, Cai Xiaofeng, Qin Jinlan, Lv Shiyun, Du Canghao, Wei Yanhong* 2018 “Inhibition of enterovirus 71 replication and viral 3C protease by quercetin” Virology Journal 15(1):116. doi: 10.1186/s12985-018-1023-6.
6. Cheng M, Li N, Wang N, Hu K, Xiao Z*, Wu P*, Wei Y* 2018 “Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network” Polyhedron 155: 313-319. doi: 10.1016/J.POLY.2018.08.052
7. Ke S *, Li N, Ke T, Shi L, Zhang Z, Fang W, Zhang Y, Wang K, Zhou R, Wan Z, Yang Z, Zhang G, Wei Y* 2018 “Synthesis and evaluation of steroidal thiazoline conjugates as potential antiviral agents” Future Medicinal Chemistry 10 (22), 2589-2605. doi: 10.4155/fmc-2018-0075
8. Ji M, Hu K*. 2017 “Recent advances in the study of hepatitis B virus covalently closed circular DNA” Virologica Sinica 32(6):454-464 doi: 10.1007/S12250-017-4009-4
9. Ye Guoguo, Sun Ge, Cheng Zhikui, Zhang Lei, Hu Kanghong, Xia Xianmin*, Zhou Yin* 2017 “p55PIK regulates alpha-fetoprotein expression through the NF-kappa B signaling pathway” Life Sciences 191:104-110 doi: 10.1016/J.LFS.2017.09.043
10. Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu et al. 2016 “Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide” IET Nanobiotechnology 10( 1): 8-12 doi: 10.1049/IET-NBT.2014.0070
11. Cheng Z, Zhi X, Sun G, Guo W, Zhao F, Hu K* 2016 “Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines” Journal of Medical Virology 2016, 88(4): 653-663. doi: 10.1002/JMV.24366
12. Ye X, Zhou M, He Y, Wan Y, Bai W, Tao S, Ren Y, Zhang X, Xu J, Liu J, Zhang J*, Hu K*, Xie Y* 2016 Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide. Scientific Reports 6: 29391. doi: 10.1038/srep29391
13. Danzhen Pan , Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang, Chunchen Wu, Xinwen Chen, Kanghong Hu et al. 2015 “Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model” PloS One 10(5):e0125658 doi: 10.1371/JOURNAL.PONE.0125658
14. Cheng Z, Sun G, Guo W, Huang Y, Sun W, Zhao F, Hu K* 2015 “Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines” Virologica Sinica 2015, 30(4): 261- 268. doi: 10.1007/S12250-015-3584-5
15. Zhou M, Huang Y, Cheng Z, Zhao F, Li J, Zhi X, Tian X, Sun W, Hu K* 2014 “Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes” Journal of Virological Methods 2014, 207: 29-37. doi: 10.1016/J.JVIROMET.2014.06.015
16. Zhou M, Zhao F, Li J, Cheng Z, Tian X, Huang Y, Zhi X and Hu K* 2014 “Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells” Journal of Virological Methods 195: 185-193. doi: 10.1016/J.JVIROMET.2013.10.010
17. Tian X, Zhao F, Sun W, Zhi X, Cheng Z, Zhou M, Hu K* 2014 “CRTC2 enhances HBV transcription and replication by inducing PGC1α expression” Virology Journal 11: 30. doi: 10.1186/1743-422X-11-30.
18. Tian X, Zhao F, Cheng Z, Zhou M, Zhi X, Li J, Hu K* 2013 “GCN5 acetyltransferase inhibits PGC1α-induced hepatitis B virus biosynthesis” Virologica Sinica 28(4):216-222. doi: 10.1007/S12250-013-3344-3
19. Chen P, Yun G, Na H, Wei F, Li J, Zhao F, Rayner S*, Hu K* 2013 “Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival” PloS One 8(4): e60098. doi: 10.1371/JOURNAL.PONE.0060098
20. Feng H, Chen P, Zhao F, Nassal M*, Hu K* 2013 “Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription” Plos One, 2013, 8: e72798. doi: 10.1371/JOURNAL.PONE.0072798
21. Pan X, Li XJ, Liu XJ, Tian XH, Hu KH. et al. 2013 “Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection” Journal of Virology 87(20):10968-10979. doi: 10.1128/JVI.01120-13
22. Wang W, Peng H, Li J, Zhao X, Zhao F, Hu K* 2013 Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector. Virus Genes 2013, 46 (3): 393-403. doi: 10.1007/S11262-013-0886-2
23. Zhao Z, Hong W, Zeng Z, Wu Y, Hu K et al. 2012 “ucroporin-M1 inhibits hepatitis B virus replication by activating the MAPK pathawy and down-regulating HNF4α in vitro and in vivo” Journal of Biological Chemistry 287(36):30181-90. doi:10.1074/jbc.M112.370312
24. Feng H , Beck J, Nassal M and Hu K* 2011 “A SELEX-Screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication” Plos One 6 (11): e27862. doi:10.1371/JOURNAL.PONE.0027862
25. Chen P , Rayner S*, and Hu K* 2011 “Advances of bioinformatics tools applied in virus epitopes prediction” Virologica Sinica 26(1):1-7 doi: 10.1007/s12250-011-3159-4
26. Hu K* 2010 “From Minu3D cultural system to aldosterone-induced tubulogenesis” Journal of Clinical Rehabilitative Tissue Engineering Research 14(2):365-369 doi:10.3969/j.issn.1673-8225.2010.02.041
27. Feng H and Hu K* 2009 “Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase” Virologica Sinica 24(6):509-517 doi: 10.1007/s12250-009-3076-6
28. Feng H and Hu K* 2008 “Aptamers against viral hepatitis from rational design to practical application” Virologica Sinica 23(5):315-320 doi:10.1007/s12250-008-2979-y
29. Minuth WW, Denk L, Hu K et al. 2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor” Central European Journal of Biology 2(3), 307-325 doi: 10.2478/S11535-007-0030-1
30. Minuth WW, Denk L and Hu K 2007 “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium” Biomaterials 28(30), 4418-4428 doi: 10.1016/J.BIOMATERIALS.2007.06.031
31. Heber S, Denk L, Hu K 2007 “Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium” Tissue Engineering 13(2), 281-292 doi:10.1089/TEN.2006.0199
32. Hu K et al. 2007 “Chemically defined medium determines the differential potency of renal stem cells” Biotechnology Journal 2(8), 992-995 doi:10.1002/BIOT.200700009
33. Hu K et al. 2005 “Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y” Biochimica Biophysica Acta 2005, 1729 (1): 14-23. doi:10.1016/J.BBAEXP.2005.03.001
34. Hu K et al. 2004 “SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription” Nucleic Acids Research 32(14): 4377-4389. doi: 10.1093/NAR/GKH772
35. Fels A, Hu K et al. 2001 “Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites” Nucleic Acids Research 29(22), 4589-4597 doi: 10.1093/NAR/29.22.4589
摘要：慢性乙型肝炎,其病原為Hepatitis B virus,簡稱HBV.中國作為HBV感染人數(shù)最多的國家,其中有二千多萬患者被確診為慢性肝炎(CHB),而CHB是導(dǎo)致肝硬化和肝癌的最主要誘因.中國科學(xué)院武漢病毒研究所研究員胡康洪帶領(lǐng)著他的學(xué)科組,致力于慢性乙型肝炎病毒的復(fù)制機(jī)理及抗病毒治療領(lǐng)域的深入研究 ……
慢性乙型肝炎，其病原為Hepatitis B virus，簡稱HBV。中國作為HBV感染人數(shù)最多的國家，其中二千多萬確診為慢性肝炎(CHB)，而CHB是導(dǎo)致肝硬化和肝癌的最主要誘因。目前，針對CHB的臨床治療主要通過注射干擾素或服用核苷(酸)類似物如拉米夫定(lamivudine)、阿地福韋(adefovir)等。然而，干擾素應(yīng)答率低，副作用大；使用核苷(酸)類似物易引起耐藥性病毒突變株的出現(xiàn)。從分子水平上理解HBV的復(fù)制機(jī)制，確立新穎的藥物干預(yù)靶標(biāo),并篩選與之相應(yīng)的有效抑制劑，是臨床實(shí)際的迫切需要，也是胡康洪博士所領(lǐng)導(dǎo)的學(xué)科組目前的主要攻關(guān)內(nèi)容。
1994年，時(shí)任研究所助理研究員的胡康洪，經(jīng)教育部公開選拔，獲得公派赴德國留學(xué)深造的機(jī)會。在德國，他很快憑借突出的表現(xiàn)獲得德國弗理德里希艾伯特基金會獎(jiǎng)學(xué)金，師從著名教授Dr. D. Riesner，在杜賽爾多夫大學(xué)物理生物研究所從事類病毒的復(fù)制機(jī)理研究。在Riesner教授的影響下漸漸對病毒RNA結(jié)構(gòu)和功能領(lǐng)域的研究產(chǎn)生了極大的興趣。于是，接下來的三年，他便一心一意在弗萊堡大學(xué)從事乙型肝炎病毒分子生物學(xué)的博士后研究。在那取得一些成果后，2003年，他轉(zhuǎn)戰(zhàn)雷根斯堡大學(xué)，作為課題組長主持領(lǐng)導(dǎo)歐盟聯(lián)合項(xiàng)目“肝纖維化的機(jī)制研究”，對乙型肝炎病毒分子生物學(xué)和肝纖維化作了深入研究，首次鑒定核因子Y-鋅指蛋白267-基質(zhì)金屬蛋白酶10信號途徑啟動肝纖維化轉(zhuǎn)分化過程，為設(shè)計(jì)逆轉(zhuǎn)肝纖維化和治療肝癌提供了新的藥物設(shè)計(jì)靶標(biāo)。從2006年4月起胡康洪在雷根斯堡大學(xué)分子和細(xì)胞解剖學(xué)研究所擔(dān)任助理教授，在承擔(dān)培養(yǎng)大學(xué)醫(yī)學(xué)博士生基礎(chǔ)課組織學(xué)和神經(jīng)解剖學(xué)的一部分教學(xué)工作之余，從事腎臟發(fā)育分子生物學(xué)和干細(xì)胞組織工程研究。他所在的研究組在世界上首創(chuàng)用聚脂羊毛作為“人工脈管”鋪設(shè)在三維培養(yǎng)系統(tǒng)中培植腎臟干細(xì)胞，使其成功分化腎小管，為腎臟發(fā)育分子生物學(xué)基礎(chǔ)研究和利用三維培養(yǎng)技術(shù)開展組織工程研究作出了重要貢獻(xiàn)。
胡康洪，男，1964年出生，德籍華人科學(xué)家，祖籍湖北武漢，博士。湖北工業(yè)大學(xué)中德生物醫(yī)學(xué)中心主任二級教授，博導(dǎo)，回國前是德國Regensburg大學(xué)教授。2008年全職回國，任中科院武漢病毒所國家重點(diǎn)實(shí)驗(yàn)室PI。長期從事病毒學(xué)和再生醫(yī)學(xué)基礎(chǔ)與應(yīng)用研究。2013年起擔(dān)任湖工大中德生物醫(yī)學(xué)中心主任。迄今已發(fā)表SCI學(xué)術(shù)論文173篇，出版專著2本，已培養(yǎng)博士、碩士30余名。國家科學(xué)技術(shù)獎(jiǎng)勵(lì)評審專家、科技部國際重大合作項(xiàng)目終審專家、教育部長江學(xué)者評審專家、湖北省相關(guān)人才入選者。
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采用HepG2.2.15細(xì)胞系和瞬時(shí)轉(zhuǎn)染攜帶HBV全基因組的質(zhì)粒的Huh7細(xì)胞系作為模型進(jìn)行研究。實(shí)驗(yàn)結(jié)果發(fā)現(xiàn)：20 微摩 KNK437 對細(xì)胞沒有毒性，在該濃度下KNK437 除HepG2.2.15 模型外，均下調(diào)HBV S表面抗原（HBsAg）和 e 抗原（HBeAg）向胞外分泌，抑制細(xì)胞內(nèi)HBV核衣殼中 DNA 合成，降低細(xì)胞內(nèi)HBV RNA 轉(zhuǎn)
導(dǎo)語：三維細(xì)胞培養(yǎng)技術(shù)是指將具有三維結(jié)構(gòu)不同材料的載體與各種不同種類的細(xì)胞在體外共同培養(yǎng), 使細(xì)胞能夠在載體的三維立體空間結(jié)構(gòu)中遷移、生長, 構(gòu)成三維的細(xì)胞-載體復(fù)合物。三維細(xì)胞培養(yǎng)技術(shù)是介于單層細(xì)胞培養(yǎng)與動物實(shí)驗(yàn)之間的一種技術(shù)，既能最大程度的模擬體內(nèi)環(huán)境，又能展現(xiàn)細(xì)胞培養(yǎng)的直觀性及條件可控性的優(yōu)勢，具有十分重要的應(yīng)用價(jià)值。在生命科學(xué)領(lǐng)域發(fā)揮的作用日益巨大。近年來隨著組織工程、生命科學(xué)和材料科學(xué)的飛速發(fā)展，人工脈管介質(zhì)的第二代三維細(xì)胞培養(yǎng)儀已亟待在工藝上進(jìn)行更新和升級，以滿足臨床醫(yī)學(xué)和生命科學(xué)市場對細(xì)胞培養(yǎng)的可靠性、穩(wěn)定性以及分化效率的追求。而這些，正是胡康洪教授和他的團(tuán)隊(duì)長期以來孜孜追求、不懈奮斗的重點(diǎn)目標(biāo)。
